Cardiovascular glycoprotein knowledge graph

A reader-facing workspace for GlycoCardioKG.

Explore 424 glycan-constrained candidate protein-disease associations, inspect strict and extended evidence support, and upload your own protein list to see whether it intersects the myocardial remodeling and endothelial-coagulation candidate module.

GlycoCardioKG workflow figure
The platform exposes the manuscript workflow as an interactive companion: candidate ranking, evidence triangulation, user-side matching, and downloadable tables.
-candidate associations
-unique candidate proteins
-strict OT-supported rows
-extended supported rows
-Reactome significant rows
Workflow 1

Query cardiovascular disease glycoprotein and glycan evidence.

Disease or subtype query

Search examples: myocardial fibrosis, myocardial infarction, cardiomyopathy, atherosclerosis.

Enter a disease to summarize matched glycoproteins and glycan evidence.

Matched glycoprotein evidence

Workflow 2

Query one protein across disease, glycan, pathway, and tissue evidence.

Workflow 3

Generate a candidate priority list with evidence-chain explanations.

Prioritization inputs

Optional: restrict to a user protein list.

Prioritized candidates

Run the builder to generate a ranked list and evidence-chain explanations.

Interactive candidate workbench

Search candidates and inspect evidence.

Select a candidate

Choose a candidate on the left to inspect its GlycoMPR components, glycan burden, Open Targets remapping, and evidence flags.

User data interaction

Upload a protein list for candidate matching.

Accepted input: UniProt IDs or protein names, one per line, CSV/TSV, or FASTA headers. The uploaded list is matched against GlycoCardioKG candidates and ranked by best GlycoMPR score.

Or paste IDs directly:

Matched results

Upload or paste a list to begin.
Evidence triangulation

Benchmark, STRING null, and pathway context.

Open Targets remapping

Strict support is limited to exact, parent-child, or same-subtype disease matches; broad CVD support is extended evidence only.

Subtype distribution

STRING project-local null

Top Reactome pathway rows

Manuscript figures

Figure browser.

Figure export README
Workflow
Figure 1: Workflow
Benchmark
Figure 3: GlycoMPR benchmark
Network
Figure 5: Candidate module
Open Targets
Figure 9: Open Targets
HPA
Figure 10: HPA contexts
Reactome
Figure 12: Reactome
Reusable outputs

Download tables for review or reuse.

GlycoMPR candidate ranking

Full candidate disease-association ranking.

Top candidate proteins

Protein-level candidate summary.

Open Targets disease-specific support

Strict and extended support remapping.

Strict / extended benchmark

Benchmark table used in the revised manuscript.

STRING null model

Project-local null comparisons.

Reactome background proxy

Background sensitivity proxy table.